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Glutathione is a naturally occurring antioxidant produced by nearly every cell in the body

In one of the few cases where rapid membraneassociated effects were compared in immature and mature cells, estradiol increased free intracellular calcium to promote progesterone synthesis in postpubertal hypothalamic astrocytes but not in neonatal astrocytes (136)

HRT does not typically affect thyroid function, but oral estrogen can increase thyroid-binding globulin levels, potentially altering thyroid medication requirements